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Calcipotriol

IUPAC name:

(1R,3S,5E)-5-{2-[(1R,3aS,4Z,7aR)-1-[(2R,3E)-5-cyclopropyl-5-hydroxypent-3-en-2-yl]-7a-methyl-octahydro-1H-inden-4-ylidene]ethylidene}-4-methylidenecyclohyytyexane-1,3-diol

Trade name:Daivobex, Dovobex, Sorilux

CAS No.:112965-21-6

Molecular Formula: C₂₇H₄₀O₃

Molar mass:412.605

Pharmacology action: This product is similar to vitamin D analogues, the pharmacodynamic properties and vitamin D₃ active metabolite of Calcitriol. In several in vitro models of this product and Calcitriol significantly inhibit cell proliferation and stimulate cell differentiation, such as both reduce the number of cells, total DNA content and radiation labeled thymidine incorporation into DNA, increase human keratinocytes and enhance the activity of the protein cross-linking enzyme, inhibit the proliferation and differentiation of epidermal cells.